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KMID : 0378019740170101339
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New Medical Journal
1974 Volume.17 No. 10 p.1339 ~ p.1349
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Circadian Rhythm in the Proliferative Activity of the Chick Duodenal Crypt Cell
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Abstract
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One day post-natal male chicks were divided into two experimental groups: AM and PM sacrificed groups.
Of the AM group, 3 chicks per hour were injected with 3H-thymidine at one hour intervals throughout the day starting from 5:00 AM, and every chick was dispatched at 6:00AM next morning. Likewise, the injection of the PM chicks was started from 2:00 PM and dispatched at 3:00 PM next day.
Each duodenum was removed and subjected into autoradiography and the cell cycle and its par￢ameters of duodenal crypts were determined and discussed in relation to reports that dealt with similar subjects.
The results reported distinctly demonstrate the circadian rhythm in the parameters analyzed. Callular proliferation activity was more prminent in PM chicks than in AM chicks.
Labelling index of PM chicks (30.4%) was significantly greater than that of AM chicks (20.7%) and the duration of S phase of PM chicks was lesser than that of AM chicks.
The generation time of PM chicks was significantly shorter than that of AM chicks and the dif￢ference between the duration of Gx phases of AM and PM groups might account mainly for the circadian influence.
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